@import url('https://fonts.googleapis.com/css2?family=DM+Sans:wght@400;500;600;700&family=Manrope:wght@400;600;700;800&display=swap');
:root{--ink:#163C46;--turquoise:#087F8C;--muted:#607E85;--line:#DCECEF;--paper:#F4F8F9;--teal:#078B9C}*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:100px}body{margin:0;color:var(--ink);background:var(--paper);font:16px/1.65 'DM Sans',sans-serif}a{color:var(--turquoise);text-decoration:none}a:hover{text-decoration:underline}button,input,select{font:inherit}button,a,input,select,summary{-webkit-tap-highlight-color:transparent}:focus-visible{outline:3px solid #078B9C;outline-offset:4px}button{cursor:pointer}header{position:sticky;top:0;z-index:10;background:#ffffffed;backdrop-filter:blur(14px);border-bottom:1px solid var(--line)}.header-inner{max-width:1240px;margin:auto;padding:18px 24px;display:flex;align-items:center;justify-content:space-between;gap:24px}.logo{display:inline-flex;align-items:center;gap:10px;flex-shrink:0;font:800 22px 'Manrope',sans-serif;color:var(--ink);letter-spacing:-1px}.logo span{color:var(--teal)}.logo small{display:block;font:10px 'DM Sans',sans-serif;letter-spacing:2px;margin-top:2px}nav{display:flex;gap:24px;flex-wrap:wrap;font-size:14px}nav [aria-current=page]{color:var(--teal);font-weight:700}main{max-width:1240px;margin:auto;padding:0 24px 64px}.hero{padding:56px 0 36px;display:grid;grid-template-columns:1.5fr 1fr;gap:50px;align-items:end}.eyebrow{text-transform:uppercase;color:var(--teal);font-size:12px;font-weight:700;letter-spacing:2px}h1,h2,h3{font-family:'Manrope',sans-serif;line-height:1.2}h1{font-size:clamp(36px,5vw,64px);letter-spacing:-2.5px;margin:16px 0 20px;font-weight:800}h1 span{color:var(--turquoise)}h2{font-size:25px;letter-spacing:-.6px}h3{font-size:20px;margin:15px 0 10px}.hero p{color:var(--muted);max-width:620px}.hero-aside{padding:24px;border-left:3px solid var(--teal);font-size:14px}.hero-aside strong{display:block;font:800 44px 'Manrope',sans-serif;color:var(--turquoise)}.notice{background:#eafaf8;border:1px solid #d2f6f2;border-radius:12px;padding:18px 22px;font-size:14px;margin:0 0 28px}.toolbar{display:grid;grid-template-columns:1fr auto;gap:16px;align-items:center;margin:30px 0 18px}input,select{padding:12px 14px;border:1px solid #bee0dd;background:#fff;border-radius:9px;color:var(--ink);width:100%;min-width:0}label{font-size:13px;font-weight:600;display:block}label input,label select{display:block;margin-top:7px;font-weight:400}.search-label{max-width:600px}.filters{display:flex;gap:8px;flex-wrap:wrap;margin:18px 0 26px}.filters button,.button{padding:10px 16px;border:1px solid var(--line);border-radius:8px;color:var(--ink);background:white;font-size:13px;display:inline-block}.filters button[aria-pressed=true],.primary{background:var(--turquoise);color:#fff;border-color:var(--turquoise)}.grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px}.card{display:flex;flex-direction:column;background:white;border:1px solid var(--line);border-radius:14px;padding:25px;transition:transform .18s,border-color .18s}.card:hover{transform:translateY(-3px);border-color:#7ECFD9}.card .category{color:var(--teal);text-transform:uppercase;letter-spacing:.8px;font-size:10px;font-weight:700}.card p{font-size:14px;color:var(--muted);margin:8px 0 22px}.card small{font-size:12px;color:var(--muted)}.card a{margin-top:auto;font-size:14px;font-weight:700}.tool-number{color:#8DBBC5;font:600 13px 'Manrope',sans-serif}.tool-feature{background:var(--ink);color:white;padding:26px 30px;border-radius:14px;margin-bottom:22px;display:flex;align-items:center;justify-content:space-between;gap:24px}.tool-feature h2{margin:4px 0 10px}.tool-feature p{margin:0;color:#c3e8e4;font-size:14px}.tool-feature a{color:white;border:1px solid #8ccbc5;white-space:nowrap}.guide{max-width:840px;margin:32px auto;background:white;border:1px solid var(--line);border-radius:18px;padding:clamp(22px,4vw,48px)}.guide h1{font-size:42px;letter-spacing:-1.5px}.guide h2{font-size:22px;margin-top:32px}.guide p,.guide li{color:#437671}.guide .meta{font-size:13px;color:var(--teal)}.guide a{overflow-wrap:anywhere}.guide details{border-top:1px solid var(--line);padding:16px 0}.guide summary{cursor:pointer;font-weight:600}.tool-layout{display:grid;grid-template-columns:1.1fr 1fr;gap:32px;margin-top:28px}.fields{display:grid;grid-template-columns:1fr 1fr;gap:18px}.fields .wide{grid-column:1/-1}.result{background:#eefcfb;border-radius:12px;padding:22px;align-self:start}.result dl{margin:0}.result dl div{padding:12px 0;border-bottom:1px solid #d1eeeb}.result dt{font-size:12px;color:var(--muted)}.result dd{margin:5px 0 0;font-size:20px;font-weight:700}.error{color:#9b341b;background:#fff1e7;padding:15px;border-radius:8px}.method{font-size:13px;color:var(--muted);margin-top:24px}.empty{padding:40px;border:1px dashed #bee0dd;text-align:center;grid-column:1/-1}.back{display:inline-block;margin-top:28px}.footer{border-top:1px solid var(--line);padding:30px 24px;font-size:13px;color:var(--muted);text-align:center}.footer a{margin:0 10px}[hidden]{display:none!important}@media(min-width:1050px){.card:first-child{border-top:3px solid var(--teal)}}@media(max-width:900px){.grid{grid-template-columns:repeat(2,minmax(0,1fr))}.hero{gap:24px}.header-inner{align-items:flex-start}nav{gap:12px}}@media(max-width:620px){.header-inner{padding:14px 18px;flex-direction:column;gap:12px}nav{font-size:12px;gap:16px}.hero{grid-template-columns:1fr;padding-top:32px;gap:10px}.hero-aside{display:none}main{padding:0 18px 40px}.grid,.tool-layout{grid-template-columns:1fr}.toolbar{grid-template-columns:1fr}.tool-feature{align-items:flex-start;flex-direction:column}.fields{grid-template-columns:1fr}.guide h1{font-size:32px}.filters button{font-size:12px;padding:8px 10px}.card{padding:22px}.guide{margin:20px 0}.tool-layout{gap:24px}}@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}.card{transition:none}.card:hover{transform:none}}
.protocol-picker{background:white;border:1px solid var(--line);border-left:4px solid var(--teal);padding:24px;border-radius:12px;max-width:840px}.protocol-picker label{font-size:15px}.protocol-picker p{font-size:13px;color:var(--muted);margin-bottom:0}.protocol-guide{margin-left:0;max-width:960px}.protocol-title{font-size:clamp(28px,4vw,42px)!important;margin:14px 0!important}.protocol-label{font-size:13px;color:var(--teal)!important}.protocol-facts{margin:28px 0}.protocol-facts>div{display:grid;grid-template-columns:180px 1fr;gap:24px;border-top:1px solid var(--line);padding:22px 0}.protocol-facts dt{font-weight:700;color:var(--turquoise);font-size:14px}.protocol-facts dd{margin:0;color:#437671}@media(max-width:620px){.protocol-facts>div{grid-template-columns:1fr;gap:8px}.protocol-picker{padding:18px}}
.research-study{border-top:2px solid var(--line);padding:24px 0 12px;margin-top:28px}.research-study h3{line-height:1.5;overflow-wrap:anywhere}.study-model{display:inline-block;background:#e7f3f2;color:#146263!important;padding:6px 12px;border-radius:6px;font-size:13px}.research-study blockquote{margin:12px 0;padding:14px 18px;border-left:3px solid var(--teal);background:#f2faf9;font-size:14px;overflow-wrap:anywhere}.research-unavailable{padding:16px 22px;background:#f2faf9;border:1px dashed #b7e2de;border-radius:10px}
.protocol-search-panel{background:#fff;border:1px solid var(--line);border-top:4px solid var(--turquoise);border-radius:14px;padding:clamp(18px,3vw,28px);margin:28px 0}.protocol-search-heading{display:flex;align-items:center;justify-content:space-between;gap:24px;margin-bottom:22px}.protocol-search-heading h2{margin:8px 0}.protocol-search-heading p{color:var(--muted);font-size:14px;margin:0}.protocol-search-heading .button{flex-shrink:0}.protocol-search-controls{display:flex;gap:10px;margin-top:8px}.protocol-search-controls .button{flex-shrink:0}.protocol-search-controls button:disabled{opacity:.5;cursor:default}#protocol-search-status{font-size:13px;color:var(--muted);margin:14px 0}.protocol-search-results{list-style:none;padding:0;margin:0;display:grid;grid-template-columns:repeat(2,minmax(0,1fr));max-height:380px;overflow-y:auto;border:1px solid var(--line);border-radius:9px;scroll-padding:8px}.protocol-search-results li{min-width:0;border-bottom:1px solid var(--line)}.protocol-search-results a{display:flex;align-items:center;justify-content:space-between;gap:12px;padding:14px 16px;color:var(--ink);height:100%;font-size:14px}.protocol-search-results a:hover{background:#eafcfa;text-decoration:none}.protocol-search-results a:focus-visible{outline-offset:-4px}.protocol-result-action{white-space:nowrap;color:var(--turquoise);font-size:12px}.protocol-no-results{grid-column:1/-1;padding:22px;color:var(--muted);font-size:14px}@media(max-width:700px){.protocol-search-heading{align-items:flex-start;flex-direction:column;gap:16px}.protocol-search-results{grid-template-columns:1fr;max-height:340px}.protocol-search-results a{padding:14px 12px}}

.protocol-guide .research-study [lang="tr"]>div+div{margin-top:16px}.protocol-guide .research-study [lang="tr"]>div>div:first-child{font-weight:700;color:var(--teal);margin-bottom:6px}.protocol-guide .research-study [lang="tr"]{overflow-wrap:anywhere}

.logo img{display:block;flex-shrink:0}.logo .logo-wordmark{color:var(--ink)}